Angela Koehler

Associate Professor

Department
Department of Biological Engineering
Technology Areas
Biotechnology: Biomanufacturing, Biomedical Devices & Systems / Therapeutics: Cell Based Therapy, Small Molecules, Proteins & Antibodies / Drug Discovery and Research Tools: Cell Lines & Organoids, Genomics & Proteomics / Diagnostics: Assays / Drug Delivery: Microparticles & Nanoparticles / Chemicals & Materials: Catalysis & Synthesis, Polymers

Pioneering research into next-generation molecular probes, transcending traditional boundaries in cancer genomics and precision medicine.

Background and Experience

Angela Koehler is an Associate Professor in the Department of Biological Engineering at MIT and an intramural member of the David H. Koch Institute for Integrative Cancer Research at MIT. She is also an Institute Member of the Broad Institute and a Founding Member of the MIT Center for Precision Cancer Medicine. Her research group aims to discover and develop functional small-molecule probes of targets emerging from patient-based genomics, including targets deemed recalcitrant to small molecule drug discovery efforts, such as transcription factors, RNA-binding proteins or cytokines. Selected probes may be developed into imaging agents, diagnostic tools, or therapeutic leads.

Technologies

Identification of Small Molecule Compounds Targeting ULK3 Kinase

Technology / Case number: #25682J
Angela Koehler / Andrea Casiraghi / Gian Dotto / Sandro Goruppi
Technology Areas: Chemicals & Materials / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

TOX Inhibitor and Molecular Glue

Technology / Case number: #25241
Angela Koehler / Bocheng Wu
Technology Areas: Chemicals & Materials / Therapeutics
License

A Generalizable, High-Throughput Method to Rapidly add Chemical Moieties to a Small Molecule Library

Technology / Case number: #22196J
Angela Koehler / Brice Curtin / Jasmin Kruell / Catherine Henry / Sebastian Pomplun / Christina Woo / Chia-fu Chang
Technology Areas: Biotechnology / Drug Discovery and Research Tools / Therapeutics
Impact Areas: Healthy Living
License

Small Molecule Inhibitors of Interleukin-4

Technology / Case number: #22186J
Angela Koehler / Arturo Vegas / Shelby Doyle / Becky Leifer / Sean Quinnell / Stephen Nestor / Kelly Tan / Luke Ceo / Daniel Sheehy
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Chimeric Degraders of Cyclin Dependent Kinase 9 with Potential Use for Cancer Therapy

Technology / Case number: #22028
Angela Koehler / Andre Richters / Julie Urgiles / Florian Kabinger / Mohammed Toure
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

Small Molecule Modulators of the Androgen Receptor

Technology / Case number: #19771
Angela Koehler / Nicholas Struntz / David Freeman / Shelby Doyle / Andre Richters
Technology Areas: Biotechnology / Therapeutics
License

Novel Max Binders Modulators of Myc-Mediated Transcription with Potential Use for Cancer Therapy

Technology / Case number: #18257
Angela Koehler / Eric Stefan / Francisco Caballero Gonzalez / Dylan Neel / Helen Evans / Nicholas Struntz / Andrew Chen
Technology Areas: Biotechnology / Therapeutics
License

Pooled Screening Identifies Genomic Features (Biomarkers) Modulating Nanoparticle-Cell Interactions

Technology / Case number: #22785J
Angela Koehler / Natalie Boehnke / Joelle Straehla / Paula Hammond
Technology Areas: Diagnostics / Drug Delivery / Therapeutics
License

Modulating Oncogenic Transcriptional Dysregulation with Small Molecule Chimeric Degraders of Cyclin-Dependent Kinase 9

Technology / Case number: #24831
Angela Koehler / Mohammed Toure / Keisuke Motoyama
Technology Areas: Chemicals & Materials / Therapeutics
Impact Areas: Healthy Living
License

Small Molecule Binders of the Oncogenic Fusion Transcription Factor PAX3-FOXO1

Technology / Case number: #23850J
Angela Koehler / Shelby Doyle / Becky Leifer / Madeleine Henley / Beat Schaefer / Marco Wachtel
Technology Areas: Biotechnology / Therapeutics
Impact Areas: Healthy Living
License

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