Inhibition of Histone Deacetylase 2 Facilitates Extinction of Aversive Memory

The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.

Researchers

Li-Huei Tsai / Stephen Haggarty / Jisong Guan / Edward Holsen / Florence Wagner / Johannes Graff

Departments: DLC Heads Science
Technology Areas: Therapeutics: Small Molecules
Impact Areas: Healthy Living

  • use of ci-994 and dinaline for the treatment of memory/cognition and anxiety disorders
    United States of America | Granted | 8,841,346

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