Chemical Formulations to Enhance Ultrasound-Mediated Gastrointestinal Delivery
This technology is related to case #17807.
This combined technology consists of an ultrasound mediated gastrointestinal drug delivery kit enhanced by chemical formulations. The invention features an elongated body with a specially designed tip that incorporates a transducer to emit ultrasound waves, providing a live view of the desired lumen. This technology is combined with compounds that interact with ultrasound to enhance drug delivery to the target location within a short treatment window. Ultrasound technology is considered a cost-effective, low-radiation exposure method for imaging the body to deliver drugs to targeted areas. By increasing efficacy and decreasing overall treatment time, this technology promotes minimally invasive techniques for delivering medication quickly, reducing stress on the body.
Researchers
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compositions and methods to enhance ultrasound-mediated delivery of pharmaceutical agents
United States of America | Published application -
compositions and methods to enhance ultrasound-mediated delivery of pharmaceutical agents
European Patent Convention | Published application -
compositions and methods to enhance ultrasound-mediated delivery of pharmaceutical agents
Canada | Published application -
compositions and methods to enhance ultrasound-mediated delivery of pharmaceutical agents
Hong Kong | Published application
Technology
The ultrasound drug delivery kit utilizes a device with an elongated body, having a proximal and distal end. The distal end connects to a specially shaped tip intended for partial insertion into a body lumen. The tip also features an opening for substance delivery from the internal chamber and incorporates a transducer to emit ultrasound waves into the body lumen, enhancing substance administration to the target tissue. In animal studies, combined use of the apparatus with a composition comprising a pharmaceutical agent and ultrasound enhancing agent has been shown to enhance delivery of material to skin and GI tissue two to four times over the delivery that can be achieved using ultrasound alone. Additionally, data from first-in-human clinical trials in healthy volunteers demonstrated that ultrasound can be locally applied in the GI tract to deliver drug in a rapid, safe and tolerable manner with no serious adverse events. This technology makes it possible to administer virtually any therapeutic class including nucleic acids directly into cells with great efficacy and accuracy to previously undruggable targets.
Problem Addressed
This invention addresses critical challenges in GI drug delivery by providing an apparatus, kit, and method for administering substances efficiently. Traditional methods struggle with delivering macromolecules and often require extensive formulation efforts even for small molecules. This technology aims to address these limitations by introducing an ultrasound-mediated device that facilitates the rapid and effective delivery of a wide range of therapeutics directly to the GI tract without extensive reformulation.
Advantages
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Novel ultrasound technology enhances imaging of tissue
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Compound combined with ultrasound technology increases delivery up to 4x traditional ultrasound alone
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Reduced treatment time
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Enhanced tissue penetration
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Improved dosage control
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Allows for the delivery of a broad range of therapeutics without the need for time-consuming and costly reformulation
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